Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | ACP3 | P15309 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29403593 | 0.81 | ESR1 (0.52) | ESR1TSHRACHEACP3ALDH1A1 | |
| SCHEMBL6220718 | 0.81 | ESR1 (0.52) | ESR1TSHRACHEACP3ALDH1A1 | |
| SCHEMBL16308863 | 0.81 | ESR1 (0.52) | ESR1TSHRACHEACP3ALDH1A1 | |
| SCHEMBL30647211 | 0.81 | ESR1 (0.52) | ESR1TSHRACHEACP3ALDH1A1 | |
| SCHEMBL16308826 | 0.81 | ESR1 (0.52) | ESR1TSHRACHEACP3ALDH1A1 | |
| SCHEMBL624799 | 0.81 | ESR1 (0.52) | ESR1TSHRACHEACP3ALDH1A1 | |
| SCHEMBL7380183 | 0.79 | ESR1 (0.50) | ESR1TSHRACHEACP3ALDH1A1 | |
| SCHEMBL4430667 | 0.78 | ESR1 (0.54) | ESR1TSHRACHEACP3ALDH1A1 | |
| SCHEMBL1248016 | 0.78 | ESR1 (0.54) | ESR1TSHRACHEACP3ALDH1A1 | |
| SCHEMBL18241957 | 0.77 | ESR1 (0.48) | ESR1TSHRACHEACP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163753-B2 | 2-(4-(4-(4-chlorophenyl)oxazol-2-yl)phenoxymethyl)-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole; bactericide; excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-04-24 | — | — | US | disclosed |
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |
| US-20080119478-A1 | 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis | OTSUKA PHAMACEUTICAL CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| US-7268247-B2 | Process for the preparation of phenylmalonic acid dinitriles | SYNGENTA CROP PROTECTION, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-20060135805-A1 | Process for the preparation of phenylmalonic acid dinitriles | SYNGENTA CROP PROTECTION, INC. | 2006-06-22 | — | — | US | disclosed |
| EP-1567482-A1 | PROCESS FOR THE PREPARATION OF PHENYLMALONIC ACID DINITRILES | Syngenta Participations AG (CH) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050607-A1 | PROCESS FOR THE PREPARATION OF PHENYLMALONIC ACID DINITRILES | SYNGENTA PARTICIPATIONS AG (CH) | 2004-06-17 | — | — | WO | disclosed |
| US-6441233-B1 | CARBONYLATION, AMIDATION; IN PRESENCE OF ACYLATION CATALYST | SOLVIAS AG (CH) | 2002-08-27 | — | — | US | disclosed |
| EP-1185506-A1 | SUBSTITUTED ARYLMALONIC ACID DINITRILES AS INTERMEDIATES FOR THE PREPARATION OF HERBICIDES | Syngenta Participations AG (CH) | 2002-03-13 | — | — | EP | disclosed |
| EP-1140796-A1 | PROCESS FOR THE PREPARATION OF AROMATIC CARBOXYLIC ACID AMIDES | Solvias AG (CH) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000078712-A1 | SUBSTITUTED ARYLMALONIC ACID DINITRILES AS INTERMEDIATES FOR THE PREPARTION OF HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000037428-A1 | PROCESS FOR THE PREPARATION OF AROMATIC CARBOXYLIC ACID AMIDES | SOLVIAS AG (CH) | 2000-06-29 | — | — | WO | disclosed |
| EP-0073413-A2 | Acylphosphine oxide compounds and their use | BASF Aktiengesellschaft (DE) | 1983-03-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119478-A1 | 2,3-Dihydro-6-Nitroimidazo (2,1-b) Oxazole Compounds for the Treatment of Tuberculosis | NR2C2, NR0B2, NR4A2 | ESR1 1871/4885TSHR 162/4885ACHE 4734/4885 |
| US-20060135805-A1 | Process for the preparation of phenylmalonic acid dinitriles | ME1, PDK2, PDK4 | ESR1 4657/4885TSHR 4577/4885ACHE 3444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.