Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12309266 | 0.82 | ALDH1A1 (0.54) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL12774647 | 0.66 | POLB (0.56) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL20960686 | 0.66 | LMNA (0.42) | POLBALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12309230 | 0.64 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL13900945 | 0.64 | POLB (0.54) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL552910 | 0.63 | ALDH1A1 (0.54) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL2465209 | 0.63 | HTT (0.58) | POLBALDH1A1KMT2AMAPTMAPK1 | |
| SCHEMBL2993237 | 0.63 | KMT2A (0.55) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL13598933 | 0.63 | ALDH1A1 (0.66) | POLBALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL16002834 | 0.63 | POLB (0.63) | POLBALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188293-B1 | 6-SUBSTITUTED SULFONYL AZABICYCLOÝ3.2.1¨OCTANES USEFUL TO INHIBIT 11 -HYDROXYSTEROID DEHYDROGENASE TYPE-1 | MERCK SHARP & DOHME (US) | 2019-05-01 | — | — | EP | disclosed |