Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5286862 | 0.78 | LMNA (0.43) | LMNATDP1ALDH1A1POLBKMT2A | |
| SCHEMBL12309230 | 0.75 | ALDH1A1 (0.52) | LMNATDP1ALDH1A1KMT2ANPC1 | |
| SCHEMBL5282272 | 0.70 | TSHR (0.51) | LMNATDP1ALDH1A1POLBKMT2A | |
| SCHEMBL5286887 | 0.70 | POLB (0.56) | LMNATDP1ALDH1A1POLBKMT2A | |
| SCHEMBL4745416 | 0.68 | LMNA (0.39) | LMNATDP1ALDH1A1POLBNLRP3 | |
| SCHEMBL18711645 | 0.66 | ALDH1A1 (0.55) | LMNATDP1ALDH1A1KMT2ANPC1 | |
| SCHEMBL20960741 | 0.66 | POLB (0.50) | LMNATDP1ALDH1A1POLBKMT2A | |
| SCHEMBL19391630 | 0.65 | RORA (0.46) | LMNATDP1ALDH1A1ALOX15POLB | |
| SCHEMBL4785395 | 0.65 | MAPT (0.55) | LMNAALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL5297518 | 0.65 | NPC1 (0.45) | LMNATDP1ALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188293-B1 | 6-SUBSTITUTED SULFONYL AZABICYCLOÝ3.2.1¨OCTANES USEFUL TO INHIBIT 11 -HYDROXYSTEROID DEHYDROGENASE TYPE-1 | MERCK SHARP & DOHME (US) | 2019-05-01 | — | — | EP | disclosed |