Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 1/20 | 0.59 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.56 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 2/20 | 0.56 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.51 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20964498 | 0.87 | PRSS1 (0.55) | GRIA1GRIN1GRIN2AF2FOLH1 | |
| SCHEMBL20964428 | 0.85 | GRIN1 (0.58) | GRIA1GRIN1GRIN2AF2FOLH1 | |
| SCHEMBL24179827 | 0.85 | PRSS1 (0.58) | GRIA1GRIN1GRIN2AFOLH1PRSS1 | |
| SCHEMBL20964423 | 0.85 | PRSS1 (0.61) | GRIA1GRIN1GRIN2AROCK2PRSS1 | |
| SCHEMBL24179828 | 0.85 | FOLH1 (0.47) | GRIA1FOLH1SIRT1SIRT2SIRT3 | |
| SCHEMBL20964419 | 0.83 | PRSS1 (0.56) | GRIA1GRIN1GRIN2AF2PRSS1 | |
| SCHEMBL20964435 | 0.83 | KISS1R (0.53) | L3MBTL1PRSS1PRSS2PRSS3 | |
| SCHEMBL24179826 | 0.82 | TLR2 (0.47) | TLR2GRIN1GRIN2ASIRT1SIRT2 | |
| SCHEMBL20964420 | 0.82 | TLR2 (0.47) | TLR2GRIN1GRIN2ASIRT1SIRT2 | |
| SCHEMBL24179818 | 0.82 | PRSS1 (0.51) | GRIA1GRIN1GRIN2AF2FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220526-B2 | Neuropeptide S receptor (NPSR) agonists | RESEARCH TRIANGLE INSTITUTE (US) | 2022-01-11 | — | — | US | disclosed |
| US-20190127419-A1 | NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS | RESEARCH TRIANGLE INSTITUTE | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127419-A1 | NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS | NPSR1, GRPR, NPBWR1 | TLR2 1090/4885GRIA1 145/4885GRIN1 191/4885 |
| US-11220526-B2 | Neuropeptide S receptor (NPSR) agonists | NPSR1, GRPR, NPBWR1 | TLR2 1090/4885GRIA1 145/4885GRIN1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.