Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25407 | 0.90 | — | — | |
| SCHEMBL12302096 | 0.83 | ALDH1A1 (0.73) | ALDH1A1MAPK1CYP2A6CA2CA12 | |
| SCHEMBL1673427 | 0.83 | ALDH1A1 (0.73) | ALDH1A1MAPK1CYP2A6CA2CA12 | |
| SCHEMBL68094 | 0.83 | ALDH1A1 (0.73) | ALDH1A1MAPK1CYP2A6CA2CA12 | |
| SCHEMBL28224117 | 0.81 | CYP2A6 (0.50) | ALDH1A1MAPK1CYP2A6CA2ALOX15 | |
| Water SCHEMBL3824552 | 0.79 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP2A6CA2CA12 | |
| SCHEMBL21518323 | 0.79 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP2A6CA2CA12 | |
| Hydrogen Sulfide SCHEMBL4123828 | 0.79 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP2A6CA2CA12 | |
| SCHEMBL1255210 | 0.79 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP2A6CA2CA12 | |
| Zinc Chloride SCHEMBL27773254 | 0.79 | CYP2A6 (0.47) | ALDH1A1MAPK1CYP2A6CA2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338565-B2 | Macrocyclic compounds for inhibition of tumor necrosis factor alpha | ENSEMBLE THERAPEUTICS CORPORATION (US) | 2012-12-25 | — | — | US | claimed |
| EP-2350031-A2 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA | Ensemble Therapeutics Corporation (US) | 2011-08-03 | — | — | EP | claimed |
| US-20100152099-A1 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA | ENSEMBLE THERAPEUTICS CORPORATION | 2010-06-17 | — | — | US | claimed |
| WO-2010022249-A2 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA | ENSEMBLE DISCOVERY CORPORATION (US) | 2010-02-25 | — | — | WO | claimed |
| CN-111491963-B | Method for producing (meth) acrylic composition, coating material containing (meth) acrylic composition, and cured body | 三菱瓦斯化学株式会社 | 2023-04-28 | — | — | CN | disclosed |
| CN-113710750-B | (meth) acrylic composition, coating material containing same, and cured product | 三菱瓦斯化学株式会社 | 2022-07-12 | — | — | CN | disclosed |
| US-20220145118-A1 | (METH)ACRYLIC COMPOSITION, PAINT AND CURING AGENT COMPRISING SAME | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2022-05-12 | — | — | US | disclosed |
| US-11326073-B1 | (meth)acrylic composition, paint and curing agent comprising same | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2022-05-10 | — | — | US | disclosed |
| CN-113710750-A | (meth) acrylic composition, coating material containing same, and cured product | 三菱瓦斯化学株式会社 | 2021-11-26 | — | — | CN | disclosed |
| CN-108603953-B | Light diffusing agent, light diffusing resin composition, and molded article | 三菱瓦斯化学株式会社 | 2021-08-24 | — | — | CN | disclosed |
| CN-109790366-B | (meth) acrylic copolymer, resin composition, molded article thereof, and method for producing molded article | 三菱瓦斯化学株式会社 | 2021-04-27 | — | — | CN | disclosed |
| CN-108822245-B | (meth) acrylic acid-based copolymer | 三菱瓦斯化学株式会社 | 2021-02-12 | — | — | CN | disclosed |
| EP-0310017-A2 | Silver halide photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |
| US-4721666-A | Photographic element | FUJI PHOTO FILM CO., LTD. (JP) | 1988-01-26 | — | — | US | disclosed |
| US-4720446-A | Color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-01-19 | — | — | US | disclosed |
| US-4596756-A | Ethylenically unsaturated monomer, unsaturated nitrile containing monomer | FUJI PHOTO FILM CO., LTD. (JP) | 1986-06-24 | — | — | US | disclosed |
| US-4497893-A | BACKING CONTAINS GELATIN AND CATIONIC POLYMER | FUJI PHOTO FILM CO., LTD. (JP) | 1985-02-05 | — | — | US | disclosed |
| EP-0129219-A2 | Photographic elements | FUJI PHOTO FILM CO., LTD. (JP) | 1984-12-27 | — | — | EP | disclosed |
| US-4374924-A | CATIONIC POLYMERS COMPRISING QUATERNIZED COPOLYMERS OF P-DIVINYLBENZENE OR A DIACRYLIC ESTER AND AN AMINO-CONTAINING ACRYLIC ESTER OR AMIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1983-02-22 | — | — | US | disclosed |
| US-4312940-A | FOR ACID DYES; REMOVABLE DURING ALKALINE PROCESSING | FUJI PHOTO FILM CO., LTD. (JP) | 1982-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152099-A1 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA | TNF, CD40, TNFRSF1A | ALDH1A1 3429/4885MAPK1 2329/4885CYP2A6 2305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.