Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.48 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20966402 | 0.90 | SPHK1 (0.58) | MMEL1CTRB1SPHK1FKBP1ACYP2C19 | |
| SCHEMBL14836855 | 0.87 | MMEL1 (0.52) | MMEL1CTRB1SPHK1FKBP1ACYP2C19 | |
| SCHEMBL2707345 | 0.85 | MMEL1 (0.58) | MMEL1CTRB1FKBP1AACEPREP | |
| SCHEMBL934366 | 0.85 | MMEL1 (0.58) | MMEL1CTRB1FKBP1AACEPREP | |
| SCHEMBL24705627 | 0.85 | SPHK1 (0.50) | MMEL1CTRB1SPHK1FKBP1ACYP2C19 | |
| SCHEMBL18626013 | 0.85 | SPHK1 (0.50) | MMEL1CTRB1SPHK1FKBP1ACYP2C19 | |
| SCHEMBL27422467 | 0.84 | MMEL1 (0.47) | MMEL1CTRB1SPHK1FKBP1ACYP2C19 | |
| SCHEMBL18734805 | 0.84 | SMN1; SMN2 (0.51) | MMEL1FKBP1ASMN1; SMN2ACE | |
| SCHEMBL19880370 | 0.84 | SMN1; SMN2 (0.51) | MMEL1FKBP1ASMN1; SMN2ACE | |
| SCHEMBL19880369 | 0.84 | SMN1; SMN2 (0.51) | MMEL1FKBP1ASMN1; SMN2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356182-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2022-11-10 | — | — | US | disclosed |
| US-11053243-B2 | Inhibitors of hepatitis C virus replication | MERCK SHARP & DOHME CORP. (US) | 2021-07-06 | — | — | US | disclosed |
| US-20200262836-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2020-08-20 | — | — | US | disclosed |
| US-20190127365-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200262836-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | MMEL1 816/4885CTRB1 285/4885SPHK1 3620/4885 |
| US-11053243-B2 | Inhibitors of hepatitis C virus replication | HAVCR2, HCCS, EIF2AK2 | MMEL1 816/4885CTRB1 285/4885SPHK1 3620/4885 |
| US-20190127365-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | MMEL1 816/4885CTRB1 285/4885SPHK1 3620/4885 |
| US-20220356182-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | MMEL1 816/4885CTRB1 285/4885SPHK1 3620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.