Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20968900 | 0.78 | PDPK1 (0.34) | — | |
| SCHEMBL20968873 | 0.78 | P2RX7 (0.34) | P2RX7ADRA1A | |
| SCHEMBL20887275 | 0.72 | TSHR (0.38) | — | |
| SCHEMBL22024185 | 0.72 | TSHR (0.38) | — | |
| SCHEMBL23073866 | 0.69 | P2RX7 (0.32) | P2RX7 | |
| SCHEMBL25043600 | 0.67 | LMNA (0.35) | P2RX7ACHEDRD3 | |
| SCHEMBL23219821 | 0.67 | PIK3CD (0.36) | — | |
| SCHEMBL22068564 | 0.66 | GNAO1 (0.38) | — | |
| SCHEMBL21214015 | 0.66 | GNAO1 (0.38) | — | |
| SCHEMBL21677540 | 0.66 | GNAO1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10759750-B2 | Beta lactams as modulators of glutamate uptake and methods for use thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| US-20190127323-A1 | Novel Beta Lactams as Modulators of Glutamate Uptake and Methods for Use Thereof | Temple University--of the Commonwealth System of Higher Education | 2019-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10759750-B2 | Beta lactams as modulators of glutamate uptake and methods for use thereof | SLC1A2, SLC1A1, SLC7A11 | CHRM1 1475/4885TLR8 956/4885P2RX7 1937/4885 |
| US-20190127323-A1 | Novel Beta Lactams as Modulators of Glutamate Uptake and Methods for Use Thereof | SLC1A2, SLC1A1, SLC7A11 | CHRM1 1184/4885TLR8 1576/4885P2RX7 2038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.