SCHEMBL20969657

SCHEMBL20969657

CCc1ccc(CCN(Cc2ccc(C(=O)O)cc2)c2nc3cccc(F)c3s2)cc1

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KARS1 Q15046 1/20 0.55
PPARD Q03181 7/20 0.40
ALDH1A1 P00352 1/20 0.39
LPAR1 Q92633 6/20 0.39
LPAR5 Q9H1C0 6/20 0.39
ALOX5 P09917 1/20 0.39
PPARG P37231 2/20 0.39
PPARA Q07869 1/20 0.39
TAS2R14 Q9NYV8 1/20 0.38
TRPM8 Q7Z2W7 1/20 0.36
AGTR1 P30556 1/20 0.36
AGTR2 P50052 1/20 0.36
RXRA P19793 1/20 0.36
RXRB P28702 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20969554 0.93 KARS1 (0.55) KARS1PPARDLPAR1LPAR5ALOX5
SCHEMBL20969749 0.92 KARS1 (0.55) KARS1PPARDALDH1A1LPAR1LPAR5
SCHEMBL20969658 0.92 KARS1 (0.55) KARS1PPARDLPAR1LPAR5ALOX5
SCHEMBL20969560 0.90 KARS1 (0.54) KARS1PPARDALDH1A1LPAR1LPAR5
SCHEMBL20969549 0.90 KARS1 (0.53) KARS1PPARDALDH1A1LPAR1LPAR5
SCHEMBL20969691 0.90 KARS1 (0.51) KARS1PPARDLPAR1LPAR5ALOX5
SCHEMBL20969618 0.90 KARS1 (0.60) KARS1PPARDLPAR1LPAR5ALOX5
SCHEMBL20969614 0.90 KARS1 (0.53) KARS1PPARDLPAR1LPAR5ALOX5
SCHEMBL20969692 0.90 KARS1 (0.53) KARS1PPARDLPAR1LPAR5ALOX5
SCHEMBL20969647 0.90 KARS1 (0.53) KARS1PPARDALDH1A1LPAR1LPAR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3483149-B1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME YUHAN CORP (KR) 2021-01-13 EP claimed
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same YUHAN CORPORATION (KR) 2019-08-20 US claimed
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same YUHAN CORPORATION (KR) 2019-05-16 US claimed
EP-3483149-A1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Yuhan Corporation (KR) 2019-05-15 EP claimed
EP-3483149-B1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME YUHAN CORP (KR) 2021-01-13 EP disclosed
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same YUHAN CORPORATION (KR) 2019-08-20 US disclosed
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same YUHAN CORPORATION (KR) 2019-05-16 US disclosed
EP-3483149-A1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Yuhan Corporation (KR) 2019-05-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same ILK, SBDS, BDKRB1 KARS1 6/4885PPARD 30/4885ALDH1A1 3073/4885
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same ILK, SBDS, BDKRB1 KARS1 6/4885PPARD 30/4885ALDH1A1 3073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.