Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2098055 | 0.88 | PIN1 (0.42) | MGMTHDAC1HDAC6HDAC4HDAC2 | |
| SCHEMBL2097013 | 0.84 | HDAC1 (0.41) | MGMTHDAC1HDAC6HDAC4HDAC2 | |
| SCHEMBL2097015 | 0.84 | HDAC1 (0.41) | MGMTHDAC1HDAC6HDAC4HDAC2 | |
| SCHEMBL2097020 | 0.82 | NPC1 (0.31) | MGMTNPC1KDM4EMAPTMAPK1 | |
| SCHEMBL2098277 | 0.81 | NPC1 (0.31) | NPC1KDM4EMAPTMAPK1RAB9A | |
| SCHEMBL2054846 | 0.76 | HDAC1 (0.43) | MGMTHDAC1HDAC6HDAC4HDAC2 | |
| SCHEMBL2098051 | 0.74 | PIN1 (0.42) | HDAC1HDAC6HDAC4HDAC2KDM4E | |
| SCHEMBL2098052 | 0.74 | PIN1 (0.42) | HDAC1HDAC6HDAC4HDAC2KDM4E | |
| SCHEMBL2098282 | 0.73 | NPC1 (0.31) | NPC1KDM4EMAPTMAPK1RAB9A | |
| SCHEMBL2098056 | 0.72 | PIN1 (0.41) | HDAC1HDAC4CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730298-B1 | SPECIFIC SUBSTRATES FOR O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | EPFL ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (CH) | 2015-11-11 | — | — | EP | disclosed |
| US-8163479-B2 | Specific substrates for O6-alkylguanine-DNA alkyltransferase | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2012-04-24 | — | — | US | disclosed |
| US-20070243568-A1 | Specific Substrates for O6-Alkylguanine-Dna Alkyltransferase | EPFL ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070243568-A1 | Specific Substrates for O6-Alkylguanine-Dna Alkyltransferase | AGT, AGXT, AGTR1 | MGMT 303/4885HDAC1 3223/4885HDAC6 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.