⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21835 | 0.71 | MEN1 (0.30) | — | |
| SCHEMBL8742 | 0.71 | — | — | |
| SCHEMBL4741585 | 0.69 | ALDH1A1 (0.35) | — | |
| SCHEMBL20589944 | 0.65 | — | — | |
| SCHEMBL20975022 | 0.52 | — | — | |
| SCHEMBL20975034 | 0.52 | — | — | |
| SCHEMBL13735762 | 0.48 | ALDH1A1 (0.65) | — | |
| SCHEMBL7857549 | 0.47 | ALDH1A1 (0.31) | — | |
| SCHEMBL241682 | 0.46 | — | — | |
| Hydrochloric Acid SCHEMBL11693353 | 0.45 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240158425-A1 | MODIFIED ADENINES | NUCLERA LTD (GB) | 2024-05-16 | — | — | US | disclosed |
| US-20240150389-A1 | MODIFIED GUANINES | NUCLERA LTD (GB) | 2024-05-09 | — | — | US | disclosed |
| EP-4196603-A1 | METHODS RELATING TO DE NOVO ENZYMATIC NUCLEIC ACID SYNTHESIS | Nuclera Nucleics Ltd (GB) | 2023-06-21 | — | — | EP | disclosed |
| US-20230175030-A1 | NUCLEIC ACID POLYMER WITH AMINE-MASKED BASES | Nuclera Nucleics Ltd. (GB) | 2023-06-08 | — | — | US | disclosed |
| US-20230151046-A1 | 5-POSITION MODIFIED PYRIMIDINES | NUCLERA LTD (GB) | 2023-05-18 | — | — | US | disclosed |
| EP-4132941-A2 | 3'-AMINOOXY-C5-SUBSTITUTED CYTOSINE NUCLEOTIDE DERIVATIVES AND THEIR USE IN A TEMPLATED AND NON-TEMPLATED ENZYMATIC NUCLEIC ACID SYNTHESIS | Nuclera Nucleics Ltd (GB) | 2023-02-15 | — | — | EP | disclosed |
| US-11505815-B2 | Compositions and methods related to non-templated enzymatic nucleic acid synthesis | NUCLERA NUCLEICS, LTD. (GB) | 2022-11-22 | — | — | US | disclosed |
| WO-2022175684-A1 | MODIFIED ADENINES | NUCLERA NUCLEICS LTD (GB) | 2022-08-25 | — | — | WO | disclosed |
| WO-2022175685-A1 | MODIFIED GUANINES | NUCLERA NUCLEICS LTD (GB) | 2022-08-25 | — | — | WO | disclosed |
| EP-3969586-A1 | NUCLEIC ACID POLYMER WITH AMINE-MASKED BASES | Nuclera Nucleics Ltd (GB) | 2022-03-23 | — | — | EP | disclosed |
| WO-2022034331-A1 | METHODS RELATING TO DE NOVO ENZYMATIC NUCLEIC ACID SYNTHESIS | NUCLERA NUCLEICS LTD (GB) | 2022-02-17 | — | — | WO | disclosed |
| WO-2020229831-A1 | NUCLEIC ACID POLYMER WITH AMINE-MASKED BASES | NUCLERA NUCLEICS LTD (GB) | 2020-11-19 | — | — | WO | disclosed |
| EP-3710461-A1 | NUCLEOTIDE DERIVATIVES CONTAINING AMINE MASKED MOIETIES AND THEIR USE IN A TEMPLATED AND NON-TEMPLATED ENZYMATIC NUCLEIC ACID SYNTHESIS | Nuclera Nucleics Ltd (GB) | 2020-09-23 | — | — | EP | disclosed |
| CN-111344296-A | Nucleotide derivatives containing amine-masked moieties and their use in templated and non-templated enzymatic nucleic acid synthesis | 核酸有限公司 | 2020-06-26 | — | — | CN | disclosed |
| US-20190144905-A1 | Novel Use | Nuclera Nucleics Ltd. (GB) | 2019-05-16 | — | — | US | disclosed |