Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15485039 | 0.83 | MTNR1A (0.53) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL2695944 | 0.80 | PSMB5 (0.53) | KDM4EALDH1A1TNFLMNAMEN1 | |
| SCHEMBL20975490 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL27252002 | 0.79 | HTR2A (0.48) | KDM4EALDH1A1HPGDHTTHSD17B10 | |
| SCHEMBL20975450 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1TNFLMNATSHR | |
| SCHEMBL18956056 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1HTTHSD17B10TNF | |
| SCHEMBL30874370 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1HTTHSD17B10TNF | |
| SCHEMBL20975444 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1HPGDTNFLMNA | |
| SCHEMBL3864912 | 0.74 | KMT2A (0.61) | KDM4EALDH1A1HPGDHSD17B10TNF | |
| SCHEMBL30379991 | 0.74 | KMT2A (0.61) | KDM4EALDH1A1HPGDHSD17B10TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210107896-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | UNIV YALE (US) | 2021-04-15 | — | — | US | disclosed |
| US-10899739-B2 | Macrophage migration inhibitory factor inhibitors, and methods of making and using same | YALE UNIVERSITY (US) | 2021-01-26 | — | — | US | disclosed |
| US-20190144424-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | YALE UNIVERSITY | 2019-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210107896-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | MIF, MMP12, METAP1 | KDM4E 651/4885ALDH1A1 2061/4885HPGD 1892/4885 |
| US-20190144424-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | MIF, MMP12, METAP1 | KDM4E 651/4885ALDH1A1 2061/4885HPGD 1892/4885 |
| US-10899739-B2 | Macrophage migration inhibitory factor inhibitors, and methods of making and using same | MIF, MMP12, METAP1 | KDM4E 651/4885ALDH1A1 2061/4885HPGD 1892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.