Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20975450 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1TSHRLMNATNF | |
| SCHEMBL20975437 | 0.80 | KDM4E (0.52) | KDM4EALDH1A1TSHRLMNATNF | |
| SCHEMBL20975444 | 0.79 | KDM4E (0.45) | KDM4EALDH1A1TSHRLMNATNF | |
| SCHEMBL31306259 | 0.74 | TNF (0.51) | KDM4EALDH1A1TSHRLMNATNF | |
| SCHEMBL12636575 | 0.72 | FPR2 (0.46) | KDM4EALDH1A1TSHRLMNARAB9A | |
| SCHEMBL29958540 | 0.72 | KMO (0.55) | ALDH1A1TSHRLMNAHTTMEN1 | |
| SCHEMBL5143014 | 0.72 | KMO (0.55) | ALDH1A1TSHRLMNAHTTMEN1 | |
| SCHEMBL26912368 | 0.72 | APOBEC3A (0.42) | KDM4EALDH1A1TNFRAB9AHTT | |
| SCHEMBL18955878 | 0.72 | PSMB1 (0.58) | KDM4EALDH1A1LMNATNFMEN1 | |
| SCHEMBL15819715 | 0.70 | JAK1 (0.58) | ALDH1A1RAB9AHTTMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210107896-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | UNIV YALE (US) | 2021-04-15 | — | — | US | disclosed |
| US-10899739-B2 | Macrophage migration inhibitory factor inhibitors, and methods of making and using same | YALE UNIVERSITY (US) | 2021-01-26 | — | — | US | disclosed |
| US-20190144424-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | YALE UNIVERSITY | 2019-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210107896-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | MIF, MMP12, METAP1 | KDM4E 651/4885ALDH1A1 2061/4885TSHR 3788/4885 |
| US-20190144424-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | MIF, MMP12, METAP1 | KDM4E 651/4885ALDH1A1 2061/4885TSHR 3788/4885 |
| US-10899739-B2 | Macrophage migration inhibitory factor inhibitors, and methods of making and using same | MIF, MMP12, METAP1 | KDM4E 651/4885ALDH1A1 2061/4885TSHR 3788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.