SCHEMBL20975833

SCHEMBL20975833

CCCNC(=O)[C@H](CCc1ccc(C#Cc2ccccc2)cc1)NC(=O)C[C@H]1CCCN(C(=N)N)C1

nearest known ligand 0.69

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
IL2RA P01589 1/20 0.69
ALB P02768 1/20 0.69
IL2 P60568 1/20 0.69
F2 P00734 14/20 0.45
PRSS1 P07477 6/20 0.45
MMP2 P08253 1/20 0.43
MMP3 P08254 1/20 0.43
MMP10 P09238 1/20 0.43
MMP8 P22894 1/20 0.43
MMP12 P39900 1/20 0.43
MMP13 P45452 1/20 0.43
ITGB1 P05556 1/20 0.43
ITGA4 P13612 1/20 0.43
CHRNB2 P17787 1/20 0.42
CHRNB4 P30926 1/20 0.42
CHRNA3 P32297 1/20 0.42
CHRNA4 P43681 1/20 0.42
PRSS2 P07478 1/20 0.41
PRSS3 P35030 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15159835 0.93 IL2RA (0.77) IL2RAALBIL2F2PRSS1
SCHEMBL19954949 0.85 IL2RA (0.74) IL2RAALBIL2F2PRSS1
SCHEMBL20761277 0.83 IL2RA (0.71) IL2RAALBIL2F2PRSS1
SCHEMBL4323684 0.83 IL2RA (0.84) IL2RAALBIL2F2PRSS1
SCHEMBL4323694 0.83 IL2RA (0.84) IL2RAALBIL2F2PRSS1
SCHEMBL4993522 0.83 IL2RA (0.84) IL2RAALBIL2F2PRSS1
SCHEMBL4323700 0.83 IL2RA (0.84) IL2RAALBIL2F2PRSS1
SCHEMBL15159838 0.82 IL2RA (0.85) IL2RAALBIL2F2ITGB1
SCHEMBL14136720 0.81 IL2RA (1.00) IL2RAALBIL2ITGB1ITGA4
SCHEMBL14136732 0.81 IL2RA (1.00) IL2RAALBIL2ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10278929-B2 Identification of stabilizers of multimeric proteins THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2019-05-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10278929-B2 Identification of stabilizers of multimeric proteins TTR, HSPBP1, HSPH1 IL2RA 3334/4885ALB 17/4885IL2 4668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.