SCHEMBL20976089

SCHEMBL20976089

C=C(C)C(=O)Nc1ccc(S(=O)(=O)O)c(NC(=O)C(=C)C)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.50
POLB P06746 3/20 0.50
L3MBTL1 Q9Y468 3/20 0.50
RXFP1 Q9HBX9 1/20 0.46
RECQL P46063 2/20 0.45
BLM P54132 1/20 0.45
ENPP2 Q13822 1/20 0.43
BAZ1A Q9NRL2 1/20 0.41
ALDH1A1 P00352 3/20 0.41
GRIK1 P39086 1/20 0.40
GRIK2 Q13002 1/20 0.40
RORC P51449 1/20 0.39
CDK1 P06493 1/20 0.38
NT5E P21589 1/20 0.36
JAK3 P52333 1/20 0.36
EGFR P00533 1/20 0.36
ERBB2 P04626 1/20 0.36
PHLPP2 Q6ZVD8 1/20 0.35
KDM4E B2RXH2 2/20 0.35
RAPGEF4 Q8WZA2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21281597 0.85 HPGD (0.39) TDP1POLBL3MBTL1RXFP1RECQL
SCHEMBL2543456 0.85 ALDH1A1 (0.55) TDP1POLBL3MBTL1RXFP1RECQL
SCHEMBL7517671 0.84 TDP1 (0.48) TDP1POLBL3MBTL1RXFP1RECQL
SCHEMBL16977408 0.83 TDP1 (0.50) TDP1POLBL3MBTL1RXFP1RECQL
SCHEMBL16272370 0.81 ENPP2 (0.57) TDP1L3MBTL1ENPP2ALDH1A1CDK1
SCHEMBL1813599 0.80 NPC1 (0.46) TDP1RXFP1ALDH1A1RORCKDM4E
SCHEMBL18310305 0.78 BAZ1A (0.47) TDP1POLBL3MBTL1RXFP1RECQL
SCHEMBL11508096 0.78 POLB (0.55) TDP1POLBL3MBTL1RXFP1RECQL
SCHEMBL10864160 0.78 POLB (0.55) TDP1POLBL3MBTL1RXFP1RECQL
SCHEMBL18310308 0.76 PRMT1 (0.52) TDP1POLBL3MBTL1RXFP1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230138382-A1 Membranes and Their Uses FUJIFILM MANUFACTURING EUROPE B.V. (NL) 2023-05-04 US disclosed
US-10279319-B2 Curable compositions and membranes FUJIFILM MANUFACTURING EUROPE B.V. (NL) 2019-05-07 US disclosed
US-20170246594-A1 Curable Compositions and Membranes FUJIFILM MANUFACTURING EUROPE B.V. (NL) 2017-08-31 US disclosed
US-9675940-B2 Curable compositions and membranes FUJIFILM MANUFACTURING EUROPE BV (NL) 2017-06-13 US disclosed