Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20977899 | 0.89 | LMNA (0.34) | CYP19A1MEN1KMT2A | |
| SCHEMBL18054226 | 0.87 | CYP19A1 (0.35) | CYP19A1TUBB1ACLYSMN1; SMN2ACACB | |
| SCHEMBL18054135 | 0.87 | ALDH1A1 (0.33) | CYP19A1TUBB1SMN1; SMN2ACACB | |
| SCHEMBL20224048 | 0.87 | KDR (0.31) | KDR | |
| SCHEMBL18054330 | 0.87 | ACACB (0.35) | KDRMEN1KMT2ASMN1; SMN2ACACB | |
| SCHEMBL18053002 | 0.84 | ALOX5 (0.31) | KDRGFER | |
| SCHEMBL18052951 | 0.78 | ALDH1A1 (0.36) | MEN1KMT2AACACB | |
| SCHEMBL18054327 | 0.77 | KDR (0.46) | KDRTUBB1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18052954 | 0.75 | HSD17B10 (0.38) | KDRMEN1KMT2ASMN1; SMN2CYP2C9 | |
| SCHEMBL17452807 | 0.75 | CYP19A1 (0.39) | CYP19A1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3261638-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE INC (US) | 2019-05-08 | — | — | EP | disclosed |