Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 11/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 9/20 | 0.50 |
| ▸ | KDM5A | P29375 | 8/20 | 0.50 |
| ▸ | KDM4A | O75164 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KDM5C | P41229 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20978802 | 0.90 | KDM4C (0.41) | KDM4CKDM5BKDM5AKDM4AKDM4E | |
| SCHEMBL20978930 | 0.87 | EPHX2 (0.41) | KDM4CKDM5BKDM5AKDM4AKDM4E | |
| SCHEMBL20978848 | 0.87 | KDM4C (0.52) | KDM4CKDM5BKDM5AKDM4AKDM4E | |
| SCHEMBL16033844 | 0.78 | KDM4C (0.77) | KDM4CKDM5BKDM5AKDM4A | |
| SCHEMBL20978918 | 0.77 | KDM5B (0.54) | KDM4CKDM5BKDM5AKDM4AKDM4E | |
| SCHEMBL20978859 | 0.76 | KDM2B (0.44) | KDM4CKDM5BKDM5AKDM4AKDM4E | |
| SCHEMBL20978805 | 0.75 | KDM5B (0.59) | KDM4CKDM5BKDM5AKDM4AKDM4E | |
| SCHEMBL16095346 | 0.73 | KDM4C (0.52) | KDM4CKDM5BKDM5AKDM4AKDM4E | |
| SCHEMBL20978807 | 0.72 | KDM5B (0.62) | KDM4CKDM5BKDM5AKDM4AKDM4E | |
| SCHEMBL20978718 | 0.72 | KDM4C (0.63) | KDM4CKDM5BKDM5AKDM4AKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969007-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2019-05-08 | — | — | EP | disclosed |