Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.58 |
| ▸ | DRD1 | P21728 | 6/20 | 0.58 |
| ▸ | DRD3 | P35462 | 6/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | HTR2C | P28335 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | HTR3A | P46098 | 3/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.58 |
| ▸ | HTR2B | P41595 | 3/20 | 0.58 |
| ▸ | HTR7 | P34969 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11486355 | 0.84 | HRH1 (0.62) | HRH1DRD1DRD3CHRM2ADRA2A | |
| SCHEMBL12909408 | 0.83 | HRH1 (0.72) | HRH1DRD1DRD3CHRM2ADRA2A | |
| SCHEMBL11487549 | 0.81 | HRH1 (0.58) | HRH1DRD1DRD3CHRM2ADRA2A | |
| SCHEMBL20978776 | 0.79 | HRH1 (0.47) | HRH1DRD1DRD3CHRM2ADRA2A | |
| Pizotyline SCHEMBL29366884 | 0.74 | DRD1 (1.00) | HRH1DRD1DRD3CHRM2ADRA2A | |
| Pizotyline SCHEMBL8771138 | 0.74 | DRD1 (1.00) | HRH1DRD1DRD3CHRM2ADRA2A | |
| Pizotyline SCHEMBL44122 | 0.74 | DRD1 (1.00) | HRH1DRD1DRD3CHRM2ADRA2A | |
| Pizotyline SCHEMBL11436430 | 0.73 | DRD1 (0.97) | HRH1DRD1DRD3CHRM2ADRA2A | |
| SCHEMBL13921290 | 0.73 | SETD7 (0.82) | HRH1DRD1DRD3CHRM2ADRA2A | |
| Ketotifen SCHEMBL4436 | 0.72 | DRD3 (1.00) | HRH1DRD1DRD3CHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2727919-B1 | BENZOCYCLOHEPTANETHIOPHENE DERIVATIVES FOR ANTI-ALLERGIC REACTIONS | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO LTD (CN) | 2019-05-08 | — | — | EP | disclosed |