SCHEMBL20983825

SCHEMBL20983825

O=C(OC(C(F)(F)F)C(F)(F)F)N1Cc2cc(Br)cnc2C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ ABHD6 Q9BV23 20/20 1.00
▸ MGLL Q99685 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20983795 0.79 ABHD6 (1.00) ABHD6MGLL
SCHEMBL15779392 0.78 ABHD6 (0.64) ABHD6
SCHEMBL29377808 0.78 ABHD6 (0.64) ABHD6
SCHEMBL21591731 0.75 ABHD6 (0.59) ABHD6
SCHEMBL21802762 0.74 ABHD6 (0.58) ABHD6
SCHEMBL16935158 0.73 ABHD6 (0.57) ABHD6
SCHEMBL20983737 0.72 ABHD6 (1.00) ABHD6MGLL
SCHEMBL20983847 0.72 ABHD6 (1.00) ABHD6MGLL
SCHEMBL20983765 0.71 ABHD6 (1.00) ABHD6MGLL
SCHEMBL29972661 0.71 ABHD6 (0.55) ABHD6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190152917-A1 ABHD6 AND DUAL ABHD6/MGL INHIBITORS AND THEIR USES MAKSCIENTIFIC, LLC 2019-05-23 — — US claimed
US-10662159-B2 ABHD6 and dual ABHD6/MGL inhibitors and their uses MAKSCIENTIFIC, LLC (US) 2020-05-26 — — US disclosed
US-20190152917-A1 ABHD6 AND DUAL ABHD6/MGL INHIBITORS AND THEIR USES MAKSCIENTIFIC, LLC 2019-05-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10662159-B2 ABHD6 and dual ABHD6/MGL inhibitors and their uses ABHD6, FAAH, FAAH2 ABHD6 1/4885MGLL 5/4885
US-20190152917-A1 ABHD6 AND DUAL ABHD6/MGL INHIBITORS AND THEIR USES ABHD6, FAAH, FAAH2 ABHD6 1/4885MGLL 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback