Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 2/20 | 0.59 |
| ▸ | ATF4 | P18848 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20989099 | 0.87 | ATF4 (0.69) | ATF4SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL16003081 | 0.85 | FKBP1A (0.64) | FKBP1AATF4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13825979 | 0.83 | FKBP1A (0.62) | FKBP1AATF4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20989269 | 0.83 | RAB9A (0.62) | FKBP1AATF4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20989159 | 0.81 | POLB (0.56) | ATF4SMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL20989271 | 0.79 | FKBP1A (0.56) | FKBP1AATF4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13849630 | 0.78 | FKBP1A (0.76) | FKBP1ASMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL25537982 | 0.78 | FKBP1A (0.64) | FKBP1ASMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL11932388 | 0.78 | GAA (0.73) | FKBP1ASMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL14437957 | 0.77 | FKBP1A (0.74) | FKBP1ASMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOG (US) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | KRAS, NRAS, HRAS | FKBP1A 3693/4885ATF4 501/4885SMN1; SMN2 4615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.