Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | GPR183 | P32249 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20989077 | 0.88 | MEN1 (0.58) | RAB9ANPC1ALDH1A1MAPTLMNA | |
| SCHEMBL20989103 | 0.85 | GPR183 (0.64) | HPGDRAB9ANPC1ALDH1A1GPR183 | |
| SCHEMBL2831262 | 0.75 | NPC1 (0.76) | HPGDRAB9ANPC1ALDH1A1GPR183 | |
| Trifluoroacetic Acid SCHEMBL18129136 | 0.73 | GPR183 (0.65) | HPGDRAB9ANPC1ALDH1A1GPR183 | |
| SCHEMBL20989309 | 0.73 | GPR183 (0.65) | RAB9AALDH1A1GPR183MAPTSMN1; SMN2 | |
| SCHEMBL1374133 | 0.73 | NPC1 (0.77) | HPGDRAB9ANPC1ALDH1A1GPR183 | |
| SCHEMBL4384365 | 0.73 | SMN1; SMN2 (0.74) | HPGDRAB9ANPC1ALDH1A1GPR183 | |
| SCHEMBL20988927 | 0.73 | POLB (0.66) | NPC1ALDH1A1LMNAKMT2APOLB | |
| SCHEMBL5370951 | 0.72 | HPGD (0.57) | HPGDRAB9ANPC1ALDH1A1GPR183 | |
| SCHEMBL4381637 | 0.72 | SMN1; SMN2 (0.73) | HPGDRAB9ANPC1ALDH1A1GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOG (US) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | KRAS, NRAS, HRAS | HPGD 2600/4885RAB9A 146/4885NPC1 3960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.