Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20989103 | 0.88 | GPR183 (0.64) | GPR183NPSR1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20989279 | 0.80 | POLB (0.61) | NPSR1HSD17B10ALDH1A1HTR1AHTR1B | |
| SCHEMBL20989196 | 0.77 | ALDH1A1 (0.61) | NPSR1SMN1; SMN2ALDH1A1HTR1AHTR1B | |
| SCHEMBL20989200 | 0.75 | ALDH1A1 (0.59) | NPSR1RAB9AALDH1A1TSHRPOLB | |
| SCHEMBL22462992 | 0.75 | NPSR1 (0.81) | NPSR1ALDH1A1HTR1AHTR1BHTR2A | |
| SCHEMBL90762 | 0.74 | GPR183 (0.52) | GPR183RAB9AFKBP1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20989269 | 0.73 | RAB9A (0.62) | GPR183NPSR1RAB9AFKBP1ASMN1; SMN2 | |
| SCHEMBL20989266 | 0.73 | HPGD (0.60) | GPR183RAB9ASMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL20989077 | 0.73 | MEN1 (0.58) | RAB9ASMN1; SMN2ALDH1A1TDP1POLB | |
| SCHEMBL29532260 | 0.73 | NPC1 (0.62) | RAB9ASMN1; SMN2EPHX2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOG (US) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | KRAS, NRAS, HRAS | GPR183 2174/4885NPSR1 2556/4885RAB9A 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.