Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | GPR183 | P32249 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367904 | 0.89 | ME2 (0.56) | LMNAGAAMAPTALDH1A1USP2 | |
| SCHEMBL5362882 | 0.85 | MMP13 (0.56) | HPGDALDH1A1TP53USP2SMN1; SMN2 | |
| SCHEMBL5366718 | 0.85 | SMN1; SMN2 (0.56) | HPGDRAB9AGPR183LMNAMAPT | |
| SCHEMBL5370693 | 0.85 | KMT2A (0.57) | RAB9ALMNAGAAMAPTALDH1A1 | |
| SCHEMBL5366075 | 0.81 | MEN1 (0.56) | HPGDGAAALDH1A1TP53MEN1 | |
| SCHEMBL5362915 | 0.75 | HDAC6 (0.60) | NPC1POLBHDAC3HDAC4HDAC1 | |
| SCHEMBL6536256 | 0.74 | KDM4E (0.55) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL5371009 | 0.74 | PKM (0.51) | HPGDRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2831262 | 0.73 | NPC1 (0.76) | HPGDRAB9ANPC1GPR183LMNA | |
| SCHEMBL5368103 | 0.72 | TPSAB1 (0.71) | RAB9ANPC1SMN1; SMN2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |