SCHEMBL21

SCHEMBL21

CCCCc1ncc(C=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 7/20 0.69
AGTR2 P50052 6/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL951175 0.83 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL5865290 0.83 AGTR1 (0.73) AGTR1AGTR2
SCHEMBL9138388 0.82 AGTR1 (0.56) AGTR1AGTR2
SCHEMBL9138396 0.82 AGTR1 (0.56) AGTR1AGTR2
SCHEMBL9162675 0.82 AGTR1 (0.84) AGTR1AGTR2
SCHEMBL9162670 0.82 AGTR1 (0.84) AGTR1AGTR2
SCHEMBL9166606 0.82 AGTR1 (0.84) AGTR1AGTR2
SCHEMBL9126087 0.82 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL33 0.81 AGTR1 (0.75) AGTR1AGTR2
SCHEMBL1906804 0.81 AGTR1 (0.59) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019048-B1 USE OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREPARATION OF DRUGS TO INCREASE THE SURVIVAL RATE OF RENAL TRANSPLANT PATIENTS MERCK SHARP DOHME ITALIA S P A (IT) 2004-01-21 EP claimed
US-6300356-B1 ADMINISTERING TO A PATIENT IN NEED OF SUCH TREATMENT A THERAPEUTICALLY EFFECTIVE AMOUNT OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST MERCK & CO., INC. 2001-10-09 US claimed
US-6201002-B1 ADMINISTERING IMIDAZOLE DERIVATIVE TO TREAT CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS MERCK & CO., INC. 2001-03-13 US claimed
EP-1059843-A1 METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST Merck & Co., Inc. (US) 2000-12-20 EP claimed
US-5962500-A HYPOSENSITVE AGENT MERCK SHARP & DOHME CORP. 1999-10-05 US claimed
WO-1999043210-A1 METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST MERCK & CO., INC. (US) 1999-09-02 WO claimed
EP-0733366-B1 Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics DU PONT (US) 1998-04-01 EP claimed
EP-0803252-A2 Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-10-29 EP claimed
EP-0533840-B1 TREATMENT OF CHRONIC RENAL FAILURE WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS DU PONT (US) 1996-12-11 EP claimed
EP-0733366-A2 Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-09-25 EP claimed
US-5153197-A Treatment of hypertension with angiotensin II blocking imidazoles E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-10-06 US claimed
US-5140037-A Administering cognition activators E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-08-18 US claimed
US-5138069-A Treating hypertension and congestive heart failure E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-08-11 US claimed
US-5128355-A Hypotensive E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-07-07 US claimed
WO-1992000067-A2 TREATMENT OF CHRONIC RENAL FAILURE WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-01-09 WO claimed
WO-1991015206-A1 TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO claimed
WO-1991014367-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-03 WO claimed
EP-0324377-A2 Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-07-19 EP claimed
WO-1989006233-A1 ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES AND COMBINATIONS THEREOF WITH DIURETICS AND NSAIDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-07-13 WO claimed
EP-0253310-A2 Angiotensin II receptor blocking imidazoles E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-01-20 EP claimed