SCHEMBL2102000

SCHEMBL2102000

CC(C)(C)OC(=O)N1CCC(NCc2ccccc2[N+](=O)[O-])CC1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.57
KDM4E B2RXH2 3/20 0.57
MEN1 O00255 1/20 0.57
KMT2A Q03164 1/20 0.57
L3MBTL1 Q9Y468 2/20 0.48
SIGMAR1 Q99720 1/20 0.47
PKM P14618 1/20 0.47
GPR119 Q8TDV5 3/20 0.46
MAPT P10636 2/20 0.45
NPC1 O15118 1/20 0.45
MAPK1 P28482 1/20 0.45
HTT P42858 1/20 0.45
RAB9A P51151 1/20 0.45
LMNA P02545 2/20 0.45
ACHE P22303 1/20 0.45
STS P08842 1/20 0.44
P2RX3 P56373 1/20 0.44
KDM1A O60341 1/20 0.43
EPHX1 P07099 1/20 0.43
THRB P10828 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28577434 0.94 ALDH1A1 (0.53) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL18928177 0.94 ALDH1A1 (0.53) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL1810009 0.91 KDM4E (0.46) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL22716715 0.89 ALDH1A1 (0.54) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL17796140 0.86 KDM4E (0.56) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL17803360 0.86 USP30 (0.45) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL27771647 0.84 KMT2A (0.58) ALDH1A1KDM4EMEN1KMT2AL3MBTL1
SCHEMBL17140284 0.83 ALDH1A1 (0.42) ALDH1A1KDM4EL3MBTL1GPR119MAPT
SCHEMBL27182163 0.83 ALDH1A1 (0.43) ALDH1A1L3MBTL1SIGMAR1GPR119MAPT
SCHEMBL2101463 0.83 ALDH1A1 (0.70) ALDH1A1KDM4EMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113924296-A 1,3, 4-oxadiazole derivative compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same 株式会社钟根堂 2022-01-11 CN disclosed
US-9951046-B2 TRPA1 modulators ALGOMEDIX, INC. (US) 2018-04-24 US disclosed
US-20170001983-A1 TRPA1 MODULATORS ALGOMEDIX, INC. 2017-01-05 US disclosed
US-8163737-B2 CGRP receptor antagonists VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-04-24 US disclosed
US-8163737-B2 CGRP receptor antagonists VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-04-24 US disclosed
US-8163737-B2 CGRP receptor antagonists VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-04-24 US disclosed
US-7834000-B2 CGRP receptor antagonists VERTEX PHARMACEUTICALS INCORPORATED (US) 2010-11-16 US disclosed
US-7834000-B2 CGRP receptor antagonists VERTEX PHARMACEUTICALS INCORPORATED (US) 2010-11-16 US disclosed
US-7834000-B2 CGRP receptor antagonists VERTEX PHARMACEUTICALS INCORPORATED (US) 2010-11-16 US disclosed
US-20090176769-A1 CGRP RECEPTOR ANTAGONISTS VERTEX PHARMACEUTICALS INCORPORATED 2009-07-09 US disclosed
US-20090176769-A1 CGRP RECEPTOR ANTAGONISTS VERTEX PHARMACEUTICALS INCORPORATED 2009-07-09 US disclosed
WO-2009020470-A2 CGRP RECEPTOR ANTAGONISTS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-02-12 WO disclosed
WO-2009020470-A2 CGRP RECEPTOR ANTAGONISTS VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-02-12 WO disclosed
WO-2008070014-A2 BIARYL KETONE-SUBSTITUTED PIPERIDINES NEUROGEN CORPORATION (US) 2008-06-12 WO disclosed
WO-2008060568-A2 AMIDE-SUBSTITUTED ARYL PIPERIDINES NEUROGEN CORPORATION (US) 2008-05-22 WO disclosed
US-20080004261-A1 CGRP receptor antagonists VERTEX PHARMACEUTICALS INCORPORATED 2008-01-03 US disclosed
US-20080004261-A1 CGRP receptor antagonists VERTEX PHARMACEUTICALS INCORPORATED 2008-01-03 US disclosed
US-20080004261-A1 CGRP receptor antagonists VERTEX PHARMACEUTICALS INCORPORATED 2008-01-03 US disclosed
WO-2007146349-A2 CGRP RECEPTOR ANTAGONISTS VERTEX PHARMACEUTICALS INCORPORATED (US) 2007-12-21 WO disclosed
US-4410528-A Hypotensive piperidine derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1983-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090176769-A1 CGRP RECEPTOR ANTAGONISTS CALCRL, CALCR, GRPR ALDH1A1 1645/4885KDM4E 4442/4885MEN1 1511/4885
US-20170001983-A1 TRPA1 MODULATORS TRPA1, TRPV1, TRPV2 ALDH1A1 1436/4885KDM4E 4615/4885MEN1 4676/4885
US-20080004261-A1 CGRP receptor antagonists CALCRL, CALCR, GRPR ALDH1A1 1645/4885KDM4E 4442/4885MEN1 1511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.