Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GNRHR | P30968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21019764 | 0.91 | ALDH1A1 (0.32) | NPSR1USP2TP53ALDH1A1KMT2A | |
| SCHEMBL19806107 | 0.90 | GNRHR (0.36) | USP2TP53ALDH1A1KMT2AMAPT | |
| SCHEMBL30526076 | 0.90 | GNRHR (0.36) | USP2TP53ALDH1A1KMT2AMAPT | |
| SCHEMBL21019917 | 0.90 | GNRHR (0.34) | USP2TP53ALDH1A1KMT2AMAPT | |
| SCHEMBL21019765 | 0.90 | PFKFB3 (0.32) | TP53ALDH1A1KMT2AMAPTHTT | |
| SCHEMBL21019766 | 0.90 | ALDH1A1 (0.33) | NPSR1TP53ALDH1A1KMT2AMAPT | |
| SCHEMBL21020131 | 0.89 | TP53 (0.33) | USP2MAPK1TP53ALDH1A1KMT2A | |
| SCHEMBL21019769 | 0.89 | ALDH1A1 (0.34) | USP2PKMMAPK1TP53ALDH1A1 | |
| SCHEMBL21020137 | 0.88 | TP53 (0.32) | USP2TP53ALDH1A1KMT2AMAPT | |
| SCHEMBL19806023 | 0.87 | GNRHR (0.36) | USP2MAPK1TP53ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-20210309647-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-10-07 | — | — | US | disclosed |
| US-11034680-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-06-15 | — | — | US | disclosed |
| US-20190152960-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152960-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | NPSR1 4745/4885USP2 972/4885PKM 716/4885 |
| US-11725000-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | NPSR1 4745/4885USP2 972/4885PKM 716/4885 |
| US-11034680-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | NPSR1 4745/4885USP2 972/4885PKM 716/4885 |
| US-20210309647-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | NPSR1 4745/4885USP2 972/4885PKM 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.