Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19105611 | 0.90 | TGFBR1 (0.35) | NR3C2TGFBR1TRPV1MAP3K12GAA | |
| SCHEMBL19954525 | 0.89 | SMN1; SMN2 (0.37) | NR3C2TGFBR1MAP3K12GAAALDH1A1 | |
| SCHEMBL19954566 | 0.87 | NR3C1 (0.36) | NR3C2TGFBR1MAP3K12ALDH1A1 | |
| SCHEMBL19954663 | 0.87 | NR3C2 (0.38) | NR3C2TGFBR1TRPV1MAP3K12GAA | |
| SCHEMBL19954553 | 0.87 | NR3C2 (0.40) | NR3C2TGFBR1TRPV1MAP3K12GAA | |
| SCHEMBL19954523 | 0.86 | TGFBR1 (0.35) | NR3C2TGFBR1TRPV1MAP3K12 | |
| SCHEMBL21024127 | 0.85 | NR3C2 (0.40) | NR3C2TGFBR1TRPV1MAP3K12GAA | |
| SCHEMBL19954664 | 0.84 | MAPK1 (0.39) | NR3C2TGFBR1TRPV1LMNAALDH1A1 | |
| SCHEMBL19954599 | 0.83 | NR3C2 (0.39) | NR3C2GAAALDH1A1MAPTTHRB | |
| SCHEMBL19954637 | 0.83 | ALDH1A1 (0.34) | NR3C2MAP3K12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080087-B1 | N-SUBSTITUTED PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORP (US) | 2019-05-22 | — | — | EP | disclosed |