Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 5/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18731895 | 0.84 | HRH1 (0.42) | ALDH1A1L3MBTL1HTTSMN1; SMN2HTR7 | |
| SCHEMBL17678294 | 0.82 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MEN1KMT2AHTR7 | |
| SCHEMBL78153 | 0.80 | REN (0.55) | RENSLC22A12ADORA2AADORA2BKMO | |
| SCHEMBL26997295 | 0.77 | ADORA2A (0.59) | LMNARENSLC22A12ADORA2AADORA2B | |
| SCHEMBL17678172 | 0.76 | ADORA2A (0.44) | SMN1; SMN2HTR7SIGMAR1ADORA2AADORA2B | |
| SCHEMBL17678136 | 0.75 | IRAK4 (0.35) | L3MBTL1HTTADORA2AADORA2BKMO | |
| SCHEMBL17678293 | 0.74 | BCHE (0.45) | ALDH1A1MEN1KMT2AHTR7SIGMAR1 | |
| SCHEMBL30860252 | 0.73 | QPCT (0.43) | LMNASIGMAR1ADORA2AADORA2BKMO | |
| SCHEMBL21025790 | 0.72 | KDM4E (0.47) | ALDH1A1SMN1; SMN2HTR1DHTR1BTMEM97 | |
| SCHEMBL15341754 | 0.72 | ADORA2A (0.55) | ALDH1A1LMNAHTTSLC22A12ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151312-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151312-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | HPSE, GAA, MAN2B1 | ALDH1A1 1376/4885LMNA 2070/4885L3MBTL1 3236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.