Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.55 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91359 | 0.83 | REN (0.46) | RENSLC22A12ADORA2AADORA2BKMO | |
| SCHEMBL12523918 | 0.83 | REN (0.54) | RENSLC22A12 | |
| SCHEMBL1051150 | 0.81 | REN (0.45) | RENSLC22A12ADORA2AADORA2BKMO | |
| SCHEMBL4257515 | 0.80 | REN (0.52) | RENSLC22A12KMO | |
| SCHEMBL13131423 | 0.80 | ADORA2A (0.44) | RENSLC22A12ADORA2AADORA2BKMO | |
| SCHEMBL21025792 | 0.80 | ALDH1A1 (0.48) | RENSLC22A12ADORA2AADORA2BKMO | |
| SCHEMBL13132264 | 0.79 | REN (0.46) | RENSLC22A12ADORA2AADORA2BKMO | |
| SCHEMBL26997295 | 0.79 | ADORA2A (0.59) | RENSLC22A12ADORA2AADORA2BKMO | |
| SCHEMBL4249553 | 0.78 | REN (0.45) | RENSLC22A12ADORA2AADORA2BKMO | |
| SCHEMBL13448565 | 0.78 | REN (0.45) | RENSLC22A12ADORA2AADORA2BKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |