Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.46 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21025783 | 0.92 | KDM4E (0.48) | KDM4ERECQLHRH3SIGMAR1TGFBR1 | |
| SCHEMBL21026152 | 0.90 | KDM4E (0.50) | KDM4ERECQLHRH3SIGMAR1TGFBR1 | |
| SCHEMBL21025785 | 0.89 | SIGMAR1 (0.51) | KDM4ESIGMAR1TGFBR1DRD2DRD4 | |
| SCHEMBL18731432 | 0.83 | TGFBR1 (0.51) | KDM4ETGFBR1DRD2DRD4DRD3 | |
| SCHEMBL21025782 | 0.82 | SIGMAR1 (0.48) | KDM4ESIGMAR1TGFBR1TGFBR2MAP3K20 | |
| SCHEMBL21026236 | 0.81 | HRH3 (0.48) | HRH3MAOB | |
| SCHEMBL17678285 | 0.80 | DRD2 (0.49) | TGFBR1DRD2DRD4DRD3TGFBR2 | |
| SCHEMBL21026153 | 0.79 | SIGMAR1 (0.51) | KDM4ESIGMAR1TGFBR1DRD2DRD4 | |
| SCHEMBL21025786 | 0.79 | TGFBR1 (0.43) | KDM4ETGFBR1MAP3K20SMN1; SMN2PRPS1 | |
| SCHEMBL23479575 | 0.78 | TDP1 (0.49) | ALDH1A1SMN1; SMN2PRPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151312-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151312-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | HPSE, GAA, MAN2B1 | KDM4E 3788/4885RECQL 1542/4885HRH3 2465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.