Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19054753 | 0.88 | MAPKAPK2 (0.52) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL16423708 | 0.85 | POLB (0.57) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL1040107 | 0.82 | POLB (0.59) | POLBROCK2TP53MAPTMGLL | |
| SCHEMBL8692140 | 0.80 | POLB (0.61) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL30076850 | 0.80 | POLB (0.57) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL27789206 | 0.78 | ROCK2 (0.62) | POLBROCK2TP53MAPTMGLL | |
| SCHEMBL31307421 | 0.77 | POLB (0.57) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL15332108 | 0.77 | POLB (0.57) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL21026892 | 0.77 | POLB (0.46) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL27562443 | 0.77 | POLB (0.68) | POLBROCK2TP53MAPTMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489232-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2019-05-29 | — | — | EP | disclosed |