Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21026994 | 0.83 | HTR2C (0.41) | POLBHTR2CSLC6A4ROCK2TP53 | |
| SCHEMBL13174634 | 0.77 | DGAT1 (0.39) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL21026796 | 0.77 | POLB (0.54) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL16423708 | 0.77 | POLB (0.57) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL7043026 | 0.76 | POLB (0.62) | POLBROCK2TP53MAPTSMN1; SMN2 | |
| SCHEMBL19054753 | 0.75 | MAPKAPK2 (0.52) | POLBROCK2TP53MAPTMAPKAPK2 | |
| SCHEMBL29186938 | 0.74 | YAP1 (0.47) | TP53MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL30001224 | 0.74 | YAP1 (0.47) | TP53MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL381069 | 0.74 | F13A1 (0.41) | POLBROCK2MAPTSMN1; SMN2RORC | |
| SCHEMBL1040107 | 0.74 | POLB (0.59) | POLBROCK2TP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489232-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2019-05-29 | — | — | EP | disclosed |