SCHEMBL21029938

SCHEMBL21029938

N#CCc1ccc(C2C(c3ccc(C(F)(F)F)cc3)C2(Cl)Cl)cc1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
KDM4E B2RXH2 3/20 0.37
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
ALOX15 P16050 1/20 0.37
BRCA1 P38398 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CYP3A4 P08684 4/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
TAAR1 Q96RJ0 1/20 0.35
NAAA Q02083 1/20 0.35
IDO1 P14902 2/20 0.34
KIF11 P52732 1/20 0.34
DAO P14920 1/20 0.34
MIF P14174 1/20 0.33
KDM1A O60341 1/20 0.33
RCOR1 Q9UKL0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21021772 0.84 IDH1 (0.31)
SCHEMBL246959 0.82 TAAR1 (0.48) ALDH1A1KDM4EKMT2ATAAR1NAAA
SCHEMBL10568208 0.77 SRD5A2 (0.46) ALDH1A1KDM4EKMT2ATAAR1NAAA
SCHEMBL2267261 0.77 KIF11 (0.57) TAAR1NAAAIDO1KIF11DAO
SCHEMBL21022307 0.76 NPC1 (0.30) HTT
SCHEMBL21022084 0.75 SLC9A1 (0.40) HTT
SCHEMBL18143988 0.70 AHR (0.42) KMT2AMEN1CYP3A4
SCHEMBL18143990 0.70 AHR (0.42) KMT2AMEN1CYP3A4
SCHEMBL18143993 0.70 AHR (0.42) KMT2AMEN1CYP3A4
SCHEMBL21021657 0.69 KDM1A (0.41) ALDH1A1KDM4EKMT2AMEN1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3283459-B1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2019-05-22 EP disclosed