Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.49 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30039450 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL21034067 | 0.96 | MEN1 (0.48) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL30038630 | 0.96 | MEN1 (0.48) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL20790150 | 0.85 | OPRM1 (0.50) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL21034824 | 0.80 | SIGMAR1 (0.47) | MEN1KMT2ALMNAPOLBAPP | |
| SCHEMBL30038985 | 0.80 | SIGMAR1 (0.47) | MEN1KMT2ALMNAPOLBAPP | |
| SCHEMBL5633353 | 0.79 | APP (0.44) | MEN1KMT2AMAPTPLIN1LMNA | |
| Hydrochloric Acid SCHEMBL15323298 | 0.78 | APP (0.44) | MEN1KMT2AMAPTPLIN1LMNA | |
| SCHEMBL4555828 | 0.78 | HDAC4 (0.50) | MEN1KMT2APOLBGAAALDH1A1 | |
| SCHEMBL1465128 | 0.77 | SIGMAR1 (0.50) | KMT2ALMNAPOLBAPPSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111372936-B | Mcl-1 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-111372936-A | Mcl-1 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2020-07-03 | — | — | CN | disclosed |
| WO-2019101144-A1 | SELECTIVE MCL-1 INHIBITOR AND PREPARATION AND USE THEREOF | 北京赛林泰医药技术有限公司 | 2019-05-31 | — | — | WO | disclosed |