Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21124133 | 0.85 | CYP3A4 (0.41) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL21036085 | 0.85 | SIGMAR1 (0.37) | SIGMAR1CHRM5CHRM3ITGB3ITGA2B | |
| SCHEMBL17011282 | 0.82 | SIGMAR1 (0.37) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL16748082 | 0.82 | SIGMAR1 (0.39) | SIGMAR1CHRM5CHRM3ITGB3ITGA2B | |
| SCHEMBL22303730 | 0.75 | ITGB3 (0.45) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL14683864 | 0.73 | HPGD (0.41) | SIGMAR1CHRM5CHRM3HPGDCHRNB2 | |
| SCHEMBL16748054 | 0.73 | HPGD (0.41) | SIGMAR1CHRM5CHRM3HPGDCHRNB2 | |
| SCHEMBL16767821 | 0.72 | DPP4 (0.48) | SIGMAR1CHRM5CHRM3HPGDCHRNB2 | |
| SCHEMBL16745496 | 0.72 | HPGD (0.40) | SIGMAR1CHRM5CHRM3HPGDCHRNB2 | |
| SCHEMBL20994238 | 0.71 | CYP3A4 (0.40) | ITGB3ITGA2BUGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489231-B1 | PIPERAZINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2021-06-09 | — | — | EP | disclosed |
| EP-3489231-A1 | PIPERAZINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2019-05-29 | — | — | EP | disclosed |