Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20482655 | 0.93 | CA1 (0.47) | CA1CA2TDP1CA12CA7 | |
| SCHEMBL22685609 | 0.84 | EPHX2 (0.41) | PDK2EPHX2NR1H4 | |
| SCHEMBL15956637 | 0.83 | CA12 (0.51) | CA1CA2TDP1CA12CA7 | |
| SCHEMBL28849065 | 0.81 | PDK2 (0.49) | TSHRPDK2MAPTALDH1A1NOTUM | |
| SCHEMBL21657055 | 0.81 | LMNA (0.45) | CA1CA2TDP1CA12CA7 | |
| SCHEMBL18291907 | 0.81 | EPHX2 (0.42) | KMT2APDK2MAPTEPHX2NR1H4 | |
| SCHEMBL21656955 | 0.81 | RXRA (0.42) | CA1CA2TDP1KMT2ATSHR | |
| SCHEMBL21656796 | 0.81 | LMNA (0.60) | MAPTMAPK1HTTL3MBTL1 | |
| SCHEMBL15505012 | 0.79 | TSHR (0.46) | CA1CA2CA12CA7CA9 | |
| SCHEMBL24852732 | 0.78 | NOTUM (0.40) | CA1CA2TDP1CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019104011-A1 | CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2019-05-31 | — | — | WO | disclosed |