Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 5/20 | 0.44 |
| ▸ | RXRB | P28702 | 5/20 | 0.44 |
| ▸ | RXRG | P48443 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21044587 | 0.90 | NOTUM (0.53) | NOTUMMAPTCFTRSMN1; SMN2KDM4E | |
| SCHEMBL9034755 | 0.84 | MAPK1 (0.48) | MAPTSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL18002991 | 0.81 | MAPT (0.42) | NOTUMMAPTCFTRSMN1; SMN2KDM4E | |
| SCHEMBL16303300 | 0.80 | NOTUM (0.47) | NOTUMMAPTCFTRSMN1; SMN2KDM4E | |
| SCHEMBL8613485 | 0.79 | NOTUM (0.63) | NOTUMMAPTCFTRKDM4EALDH1A1 | |
| SCHEMBL15832435 | 0.79 | MAPT (0.56) | NOTUMMAPTCFTRSMN1; SMN2KDM4E | |
| SCHEMBL19182234 | 0.79 | RXRA (0.58) | SMN1; SMN2ALDH1A1RXRARXRBRXRG | |
| SCHEMBL2088462 | 0.79 | CFTR (0.53) | NOTUMMAPTCFTRSMN1; SMN2KDM4E | |
| SCHEMBL16505957 | 0.79 | NOTUM (0.46) | NOTUMMAPTCFTRSMN1; SMN2KDM4E | |
| SCHEMBL30261881 | 0.79 | NOTUM (0.46) | NOTUMMAPTCFTRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191451-B1 | 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME | OKINAWA INST SCIENCE & TECH SCHOOL CORP (JP) | 2019-06-05 | — | — | EP | claimed |