Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclofenil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 3/20 | 0.94 |
| ▸ | ESR2 known ✓ | Q92731 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.94 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.94 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.94 |
| ▸ | AR | P10275 | 1/20 | 0.94 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.94 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.94 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.94 |
| ▸ | ELANE | P08246 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.44 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclofenil SCHEMBL132246 | 0.97 | ESR1 (1.00) | ESR1PGRCHRM2ADORA3AR | |
| Cyclofenil SCHEMBL11222765 | 0.97 | ESR1 (1.00) | ESR1PGRCHRM2ADORA3AR | |
| Cyclofenil SCHEMBL6340459 | 0.95 | ESR1 (0.97) | ESR1PGRCHRM2ADORA3AR | |
| Cyclofenil SCHEMBL9478209 | 0.91 | ESR1 (0.88) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL407238 | 0.86 | ESR1 (0.78) | ESR1PGRCHRM2ADORA3AR | |
| Cyclofenil SCHEMBL10433244 | 0.80 | PGR (0.69) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL8845652 | 0.79 | ESR1 (0.64) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL16265205 | 0.74 | ESR1 (0.60) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL9339013 | 0.72 | ELANE (0.83) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL269329 | 0.72 | LMNA (0.80) | ESR1PGRCHRM2ADORA3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190171102-A1 | SOLUTION, SOLUTION STORAGE BODY, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, PATTERN FORMING METHOD, AND MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE | FUJIFILM CORPORATION (JP) | 2019-06-06 | — | — | US | claimed |
| US-20190171102-A1 | SOLUTION, SOLUTION STORAGE BODY, ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, PATTERN FORMING METHOD, AND MANUFACTURING METHOD OF SEMICONDUCTOR DEVICE | FUJIFILM CORPORATION (JP) | 2019-06-06 | — | — | US | disclosed |