Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ANPEP | P15144 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19520682 | 1.00 | NPC1 (0.50) | NPC1PKMRAB9AALDH1A1MAPT | |
| SCHEMBL19520681 | 1.00 | NPC1 (0.50) | NPC1PKMRAB9AALDH1A1MAPT | |
| SCHEMBL19520702 | 0.87 | ADAMTS5 (0.47) | NPC1RAB9AALDH1A1NPSR1ANPEP | |
| SCHEMBL19534376 | 0.87 | ADAMTS5 (0.47) | NPC1RAB9AALDH1A1NPSR1ANPEP | |
| SCHEMBL19520703 | 0.87 | ADAMTS5 (0.47) | NPC1RAB9AALDH1A1NPSR1ANPEP | |
| SCHEMBL21082083 | 0.85 | ALDH1A1 (0.46) | NPC1PKMRAB9AALDH1A1MAPT | |
| SCHEMBL21046303 | 0.85 | ALDH1A1 (0.46) | NPC1PKMRAB9AALDH1A1MAPT | |
| SCHEMBL31078987 | 0.85 | ALDH1A1 (0.46) | NPC1PKMRAB9AALDH1A1MAPT | |
| SCHEMBL19520686 | 0.85 | ALDH1A1 (0.46) | NPC1PKMRAB9AALDH1A1MAPT | |
| SCHEMBL19520685 | 0.85 | ALDH1A1 (0.46) | NPC1PKMRAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4286001-A2 | BENZOYLGLYCINE DERIVATIVES AND METHODS OF MAKING AND USING SAME | Duke University (US) | 2023-12-06 | — | — | EP | disclosed |
| US-20210206715-A1 | Benzoylglycine Derivatives and Methods of Making and Using Same | DUKE UNIVERSITY (US) | 2021-07-08 | — | — | US | disclosed |
| US-11034649-B2 | Benzoylglycine derivatives and methods of making and using same | DUKE UNIVERSITY (US) | 2021-06-15 | — | — | US | disclosed |
| US-10550074-B2 | Benzoylglycine derivatives and methods of making and using same | DUKE UNIVERSITY (US) | 2020-02-04 | — | — | US | disclosed |
| US-20190169114-A1 | Benzoylglycine Derivatives and Methods of Making and Using Same | DUKE UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210206715-A1 | Benzoylglycine Derivatives and Methods of Making and Using Same | B3GAT3, GLO1, GLMN | NPC1 3680/4885PKM 1890/4885RAB9A 1659/4885 |
| US-11034649-B2 | Benzoylglycine derivatives and methods of making and using same | B3GAT3, GLO1, GLMN | NPC1 3680/4885PKM 1890/4885RAB9A 1659/4885 |
| US-20190169114-A1 | Benzoylglycine Derivatives and Methods of Making and Using Same | B3GAT3, GLO1, GLMN | NPC1 3680/4885PKM 1890/4885RAB9A 1659/4885 |
| US-10550074-B2 | Benzoylglycine derivatives and methods of making and using same | B3GAT3, GLO1, GLMN | NPC1 3680/4885PKM 1890/4885RAB9A 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.