Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PON1 | P27169 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL21046360 | 0.96 | XDH (0.51) | XDHAPAF1CA1CA2KMT2A | |
| Bicarbonate SCHEMBL30731333 | 0.96 | XDH (0.51) | XDHAPAF1CA1CA2KMT2A | |
| SCHEMBL2218265 | 0.90 | XDH (0.57) | XDHAPAF1CA1CA2KMT2A | |
| Bromide SCHEMBL2214307 | 0.88 | XDH (0.60) | XDHAPAF1CA1CA2KMT2A | |
| SCHEMBL10326026 | 0.88 | XDH (0.60) | XDHAPAF1CA1CA2KMT2A | |
| SCHEMBL10326021 | 0.84 | XDH (0.56) | XDHAPAF1CA1CA2KMT2A | |
| Hydrochloric Acid SCHEMBL30589704 | 0.84 | XDH (0.51) | XDHAPAF1CA1CA2KMT2A | |
| SCHEMBL16882287 | 0.77 | XDH (0.45) | XDHAPAF1CA1CA2KMT2A | |
| SCHEMBL26921378 | 0.77 | XDH (0.48) | XDHAPAF1CA1CA2KMT2A | |
| SCHEMBL13134053 | 0.76 | XDH (0.51) | XDHAPAF1CA1CA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840766-B2 | Etching metal using N-heterocyclic carbenes | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2023-12-12 | — | — | US | disclosed |
| US-11008291-B2 | Methods of forming carbene-functionalized composite materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2021-05-18 | — | — | US | disclosed |
| US-20200283911-A1 | ETCHING METAL USING N-HETEROCYCLIC CARBENES | GREENCENTRE CANADA (CA) | 2020-09-10 | — | — | US | disclosed |
| US-20190169132-A1 | Methods of Forming Carbene-Functionalized Composite Materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11008291-B2 | Methods of forming carbene-functionalized composite materials | VCL, CHN2, CA3 | XDH 2512/4885APAF1 1220/4885CA1 18/4885 |
| US-20190169132-A1 | Methods of Forming Carbene-Functionalized Composite Materials | VCL, CHN2, CA3 | XDH 2512/4885APAF1 1220/4885CA1 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.