Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19859803 | 1.00 | ALDH1A1 (0.41) | ALDH1A1CA2CA1L3MBTL1KDM4E | |
| SCHEMBL21047286 | 1.00 | ALDH1A1 (0.41) | ALDH1A1CA2CA1L3MBTL1KDM4E | |
| SCHEMBL21047287 | 1.00 | ALDH1A1 (0.41) | ALDH1A1CA2CA1L3MBTL1KDM4E | |
| SCHEMBL21047356 | 0.79 | GAA (0.44) | ALDH1A1CA2CA1L3MBTL1KDM4E | |
| SCHEMBL21047358 | 0.79 | GAA (0.44) | ALDH1A1CA2CA1L3MBTL1KDM4E | |
| SCHEMBL21047355 | 0.79 | GAA (0.44) | ALDH1A1CA2CA1L3MBTL1KDM4E | |
| SCHEMBL1933936 | 0.77 | L3MBTL1 (0.43) | CA2CA1L3MBTL1ALDH3A1POLB | |
| SCHEMBL1933932 | 0.77 | L3MBTL1 (0.43) | CA2CA1L3MBTL1ALDH3A1POLB | |
| SCHEMBL1933934 | 0.77 | L3MBTL1 (0.43) | CA2CA1L3MBTL1ALDH3A1POLB | |
| SCHEMBL1933935 | 0.77 | L3MBTL1 (0.43) | CA2CA1L3MBTL1ALDH3A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | METAP2, DNPEP, FOLH1 | ALDH1A1 608/4885CA2 894/4885CA1 937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.