Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048260 | 0.80 | MAPK1 (0.37) | HTTKDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL14626893 | 0.79 | ALDH1A1 (0.46) | HTTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL21048258 | 0.71 | KDM4E (0.34) | HTTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL4657588 | 0.70 | KDM4E (0.41) | HTTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL21076006 | 0.68 | KDM4E (0.33) | HTTKDM4ETSHRMEN1KMT2A | |
| SCHEMBL3174550 | 0.63 | HTT (0.36) | HTTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL21048241 | 0.63 | PKM (0.38) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL29658655 | 0.62 | KMT2A (0.39) | HTTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL19717028 | 0.62 | KMT2A (0.39) | HTTALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL12716504 | 0.61 | HRH4 (0.35) | ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3720860-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | Vanderbilt University (US) | 2020-10-14 | — | — | EP | disclosed |
| US-10736898-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2020-08-11 | — | — | US | disclosed |
| US-10736898-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2020-08-11 | — | — | US | disclosed |
| CN-111433212-A | Positive allosteric modulators of muscarinic acetylcholine receptor M4 | 范德比尔特大学 | 2020-07-17 | — | — | CN | disclosed |
| WO-2019113179-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2019-06-13 | — | — | WO | disclosed |
| US-20190167688-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
| US-20190167688-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10736898-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM5, CHRM2 | HTT 1341/4885ALDH1A1 3940/4885KDM4E 862/4885 |
| US-20190167688-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | HTT 1341/4885ALDH1A1 3940/4885KDM4E 862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.