Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048258 | 0.78 | KDM4E (0.34) | KDM4EMEN1GLATSHRHTT | |
| SCHEMBL21048260 | 0.72 | MAPK1 (0.37) | KDM4EMEN1GLAHTTKMT2A | |
| SCHEMBL14155640 | 0.70 | KDM4E (0.41) | KDM4EMEN1GLATSHRHTT | |
| SCHEMBL3174550 | 0.70 | HTT (0.36) | KDM4EMEN1GLATSHRHTT | |
| SCHEMBL21048241 | 0.69 | PKM (0.38) | KDM4EMEN1TSHRKMT2A | |
| SCHEMBL21048255 | 0.68 | HTT (0.35) | KDM4EMEN1TSHRHTTKMT2A | |
| SCHEMBL5809944 | 0.67 | PDE4B (0.51) | KDM4EMEN1HTTKMT2A | |
| SCHEMBL24233046 | 0.65 | HTT (0.58) | KDM4EMEN1GLATSHRHTT | |
| SCHEMBL20851218 | 0.65 | KDM4E (0.34) | KDM4EMEN1GLATSHRHTT | |
| SCHEMBL19717028 | 0.64 | KMT2A (0.39) | KDM4EMEN1GLAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10736898-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2020-08-11 | — | — | US | disclosed |
| US-20190167688-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10736898-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM4, CHRM5, CHRM2 | KDM4E 862/4885MEN1 3361/4885GLA 3343/4885 |
| US-20190167688-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM4, CHRM5, CHRM2 | KDM4E 862/4885MEN1 3361/4885GLA 3343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.