Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17258893 | 0.77 | ALDH1A1 (0.53) | ALDH1A1JAK2KMT2AMEN1HSD17B10 | |
| SCHEMBL3557822 | 0.77 | CYP1A2 (0.48) | ALDH1A1KMT2AMEN1POLBP2RX7 | |
| Hydrochloric Acid SCHEMBL21048872 | 0.76 | JAK2 (0.39) | ALDH1A1JAK2TYK2JAK3KMT2A | |
| SCHEMBL26519237 | 0.74 | KMT2A (0.50) | ALDH1A1KMT2AMEN1HSD17B10POLB | |
| SCHEMBL21048789 | 0.73 | JAK2 (0.43) | ALDH1A1JAK2TYK2JAK3KMT2A | |
| SCHEMBL4681470 | 0.70 | BDKRB1 (0.49) | — | |
| SCHEMBL20957058 | 0.70 | CYP1A2 (0.46) | POLBP2RX7TSHR | |
| Acetic Acid SCHEMBL1627732 | 0.69 | KMT2A (0.41) | ALDH1A1JAK2TYK2JAK3KMT2A | |
| SCHEMBL21048880 | 0.69 | ALDH1A1 (0.48) | ALDH1A1JAK2TYK2JAK3KMT2A | |
| SCHEMBL20238602 | 0.69 | SCN8A (0.48) | ALDH1A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |