Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 8/20 | 0.43 |
| ▸ | JAK1 | P23458 | 8/20 | 0.43 |
| ▸ | TYK2 | P29597 | 8/20 | 0.43 |
| ▸ | JAK3 | P52333 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17258747 | 0.86 | ALDH1A1 (0.45) | ALDH1A1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21048789 | 0.86 | JAK2 (0.43) | ALDH1A1PTK2JAK2JAK1TYK2 | |
| SCHEMBL21048852 | 0.83 | ALDH1A1 (0.42) | ALDH1A1PTK2JAK2JAK1TYK2 | |
| SCHEMBL21048855 | 0.83 | JAK2 (0.44) | ALDH1A1JAK2JAK1TYK2JAK3 | |
| SCHEMBL2181531 | 0.83 | NPC1 (0.46) | ALDH1A1NPC1RAB9AKMT2AGAA | |
| SCHEMBL17258893 | 0.82 | ALDH1A1 (0.53) | ALDH1A1PTK2JAK2NPSR1KMT2A | |
| SCHEMBL21048914 | 0.81 | PTK2 (0.44) | ALDH1A1PTK2JAK2JAK1TYK2 | |
| SCHEMBL16569947 | 0.80 | ALDH1A1 (0.44) | ALDH1A1PTK2JAK2JAK1TYK2 | |
| SCHEMBL21048876 | 0.79 | PTK2 (0.43) | ALDH1A1PTK2JAK2JAK1TYK2 | |
| SCHEMBL12409789 | 0.77 | CYP19A1 (0.40) | ALDH1A1PTK2JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |