Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.44 |
| ▸ | TYK2 | P29597 | 6/20 | 0.44 |
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | PER2 | O15055 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17258994 | 0.85 | ALDH1A1 (0.42) | JAK2TYK2JAK3JAK1ALDH1A1 | |
| SCHEMBL28840926 | 0.84 | TP53 (0.48) | JAK2TYK2JAK3JAK1TP53 | |
| SCHEMBL17258776 | 0.78 | JAK2 (0.42) | JAK2TYK2JAK3JAK1TP53 | |
| SCHEMBL1290793 | 0.76 | ESR1 (0.52) | PER2ALDH1A1TDP1ESR1MEN1 | |
| SCHEMBL14479721 | 0.75 | CLK2 (0.49) | JAK2JAK3ALDH1A1MEN1KMT2A | |
| SCHEMBL17258939 | 0.75 | TP53 (0.50) | JAK2TYK2JAK3JAK1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL17258792 | 0.73 | JAK2 (0.40) | JAK2TYK2JAK3JAK1PER2 | |
| SCHEMBL14820 | 0.72 | ESR1 (0.60) | PER2TDP1ESR1MEN1KMT2A | |
| SCHEMBL10993904 | 0.70 | ESR1 (0.43) | TDP1ESR1L3MBTL1NR1I2 | |
| SCHEMBL19337065 | 0.70 | ALDH1A1 (0.47) | JAK2TYK2JAK3JAK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |