Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.45 |
| ▸ | TYK2 | P29597 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17258939 | 0.92 | TP53 (0.50) | TP53JAK2TYK2JAK3JAK1 | |
| SCHEMBL21048978 | 0.87 | TP53 (0.52) | TP53JAK2TYK2JAK3JAK1 | |
| SCHEMBL21048878 | 0.84 | JAK2 (0.44) | TP53JAK2TYK2JAK3JAK1 | |
| SCHEMBL17258776 | 0.83 | JAK2 (0.42) | TP53JAK2TYK2JAK3JAK1 | |
| SCHEMBL21048854 | 0.81 | PTGER1 (0.44) | TP53JAK2TYK2JAK3JAK1 | |
| SCHEMBL17258893 | 0.78 | ALDH1A1 (0.53) | TP53JAK2MEN1KMT2AL3MBTL1 | |
| SCHEMBL21048813 | 0.77 | TP53 (0.41) | TP53JAK2TYK2JAK3JAK1 | |
| Trifluoroacetic Acid SCHEMBL17258792 | 0.77 | JAK2 (0.40) | JAK2TYK2JAK3JAK1MEN1 | |
| SCHEMBL17258976 | 0.76 | TP53 (0.42) | TP53JAK2TYK2JAK3MEN1 | |
| SCHEMBL21048938 | 0.73 | RECQL (0.40) | TP53MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459048-A | Pyrazolopyridines and pyrazolopyrimidines | 辉瑞公司 | 2017-02-22 | — | — | CN | disclosed |