Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21048830 | 0.82 | HTT (0.40) | TSHRMAPK1KDM4EKMT2AJAK2 | |
| SCHEMBL21048766 | 0.82 | PSEN1 (0.44) | TSHRKMT2AJAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL21048963 | 0.81 | PSEN1 (0.43) | TSHRKMT2AJAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL21048779 | 0.80 | CYP19A1 (0.41) | DPP4DPP9DPP7SLC6A4MPO | |
| Hydrochloric Acid SCHEMBL21048765 | 0.78 | HTT (0.41) | TSHRKDM4EALDH1A1HTT | |
| SCHEMBL21048835 | 0.78 | JAK2 (0.44) | TSHRMAPK1KDM4EKMT2AJAK2 | |
| SCHEMBL1291494 | 0.78 | ALDH1A1 (0.44) | KMT2AHSD17B10JAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL21048863 | 0.76 | ALDH1A1 (0.43) | KMT2AHSD17B10JAK2JAK1TYK2 | |
| SCHEMBL29907739 | 0.73 | MPO (0.41) | SLC6A4MPO | |
| SCHEMBL240928 | 0.73 | MPO (0.43) | SLC6A4MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |