Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.44 |
| ▸ | JAK1 | P23458 | 6/20 | 0.44 |
| ▸ | TYK2 | P29597 | 6/20 | 0.44 |
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048855 | 0.87 | JAK2 (0.44) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL21048821 | 0.85 | ALDH1A1 (0.49) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL21048789 | 0.84 | JAK2 (0.43) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL21048810 | 0.82 | GAA (0.47) | TSHRTP53NPC1RAB9AALDH1A1 | |
| SCHEMBL21048978 | 0.81 | TP53 (0.52) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL21048903 | 0.78 | DPP4 (0.42) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL7554663 | 0.74 | LMNA (0.44) | KMT2AL3MBTL1TSHRMAPK1KDM4E | |
| SCHEMBL21048804 | 0.72 | JAK2 (0.41) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL21048857 | 0.71 | HTT (0.39) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL17258939 | 0.71 | TP53 (0.50) | JAK2JAK1TYK2JAK3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |