Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.49 |
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21049826 | 0.88 | TSHR (0.64) | KDM4EALDH1A1HRH3USP2CYP1A2 | |
| SCHEMBL21049806 | 0.82 | KDM4E (0.52) | KDM4EALDH1A1HRH3USP2HPGD | |
| SCHEMBL22401399 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1HRH3RAB9A | |
| SCHEMBL20234897 | 0.79 | ALDH1A1 (0.62) | KDM4EALDH1A1HRH3USP2HPGD | |
| SCHEMBL21049821 | 0.79 | ALDH1A1 (0.44) | KDM4EALDH1A1HRH3MAOBUSP2 | |
| SCHEMBL21049815 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1HRH3RAB9A | |
| SCHEMBL678629 | 0.75 | KDM4E (0.79) | KDM4EALDH1A1HRH3USP2HPGD | |
| SCHEMBL20231184 | 0.74 | RAB9A (0.59) | KDM4EALDH1A1HRH3USP2HPGD | |
| SCHEMBL14093238 | 0.74 | HRH3 (0.78) | KDM4EALDH1A1HRH3MAOBUSP2 | |
| SCHEMBL26382883 | 0.72 | RAB9A (0.69) | KDM4EALDH1A1HRH3USP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3707125-A1 | CAFFEIC ACID DERIVATIVES FOR TREATING HYPERPROLIFERATIVE DISEASES | Board Of Regents, The University Of Texas System (US) | 2020-09-16 | — | — | EP | disclosed |
| US-10703721-B2 | Caffeic acid derivatives and uses thereof | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190177276-A1 | CAFFEIC ACID DERIVATIVES AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703721-B2 | Caffeic acid derivatives and uses thereof | GLS, GLS2, NCOA2 | KDM4E 1666/4885ALDH1A1 204/4885HRH3 3249/4885 |
| US-20190177276-A1 | CAFFEIC ACID DERIVATIVES AND USES THEREOF | GLS, GLS2, NCOA2 | KDM4E 1666/4885ALDH1A1 204/4885HRH3 3249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.