Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21050843 | 0.86 | ALDH1A1 (0.55) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL25419709 | 0.83 | ALDH1A1 (0.57) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL30351187 | 0.83 | ALDH1A1 (0.57) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL18450256 | 0.83 | ALDH1A1 (0.57) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL7694200 | 0.79 | ALDH1A1 (0.63) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL5591996 | 0.77 | ALDH1A1 (0.59) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL21136847 | 0.76 | ALDH1A1 (0.59) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL15010536 | 0.76 | ALDH1A1 (0.59) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL16858412 | 0.75 | ALDH1A1 (0.65) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL16619576 | 0.75 | ALDH1A1 (0.64) | ALDH1A1CYP1A2CYP3A4TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597405-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2020-03-24 | — | — | US | disclosed |
| US-20190177338-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | US | disclosed |
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |
| US-20190177338-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177338-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, MCL1 | ALDH1A1 26/4885CYP1A2 106/4885CYP3A4 322/4885 |
| US-10597405-B2 | Chemical compounds | MKI67, CCNI, MCL1 | ALDH1A1 26/4885CYP1A2 106/4885CYP3A4 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.